The Unfolded Protein Response Plays a Predominant Homeostatic Role in Response to Mitochondrial Stress in Pancreatic Stellate Cells

Activated pancreatic stellate cells (PaSC) are key participants in the stroma of pancreatic cancer, secreting extracellular matrix proteins and inflammatory mediators. Tumors are poorly vascularized, creating metabolic stress conditions in cancer and stromal cells that necessitate adaptive homeostat...

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Veröffentlicht in:PLoS One
Hauptverfasser: Su, Hsin-Yuan, Waldron, Richard T., Gong, Raymond, Ramanujan, V. Krishnan, Pandol, Stephen J., Lugea, Aurelia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743835/
https://ncbi.nlm.nih.gov/pubmed/26849807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148999
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