Altered short-term synaptic plasticity and reduced muscle strength in mice with impaired regulation of presynaptic Ca(V)2.1 Ca(2+) channels

Facilitation and inactivation of P/Q-type calcium (Ca(2+)) currents through the regulation of voltage-gated Ca(2+) (Ca(V)) 2.1 channels by Ca(2+) sensor (CaS) proteins contributes to the facilitation and rapid depression of synaptic transmission in cultured neurons that transiently express Ca(V)2.1...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Nanou, Evanthia, Yan, Jin, Whitehead, Nicholas P., Kim, Min Jeong, Froehner, Stanley C., Scheuer, Todd, Catterall, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743804/
https://ncbi.nlm.nih.gov/pubmed/26755585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524650113
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