The Mitotic Kinesin KIF11 is a Central Driver of Invasion, Proliferation, and Self Renewal in Glioblastoma

The proliferative and invasive nature of malignant cancers drives lethality. In glioblastoma, these two processes are presumed mutually exclusive and hence termed “go or grow”. Here, we identified a molecular target that shuttles between these disparate cellular processes—the molecular motor KIF11....

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Venere, Monica, Horbinski, Craig M., Crish, James F., Jin, Xun, Vasanji, Amit, Major, Jennifer, Burrows, Amy, Chang, Cathleen, Prokop, John, Wu, Quilian, Sims, Peter A., Canoll, Peter, Summers, Matthew K., Rosenfeld, Steven S., Rich, Jeremy N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743764/
https://ncbi.nlm.nih.gov/pubmed/26355032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac6762
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