Pirfenidone and nintedanib modulate properties of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease with a poor prognosis. Fibroblasts and myofibroblasts are the key cells in the fibrotic process. Recently two drugs, pirfenidone and nintedanib, were approved for clinical use as they are able to slow down the disease progr...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Respir Res
Main Authors: Lehtonen, Siri T., Veijola, Anniina, Karvonen, Henna, Lappi-Blanco, Elisa, Sormunen, Raija, Korpela, Saara, Zagai, Ulrika, Sköld, Magnus C., Kaarteenaho, Riitta
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743320/
https://ncbi.nlm.nih.gov/pubmed/26846335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-016-0328-5
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