Molecular Basis of Filtering Carbapenems by Porins from β-Lactam-resistant Clinical Strains of Escherichia coli

Integral membrane proteins known as porins are the major pathway by which hydrophilic antibiotics cross the outer membrane of Gram-negative bacteria. Single point mutations in porins can decrease the permeability of an antibiotic, either by reduction of channel size or modification of electrostatics...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Bajaj, Harsha, Scorciapino, Mariano A., Moynié, Lucile, Page, Malcolm G. P., Naismith, James H., Ceccarelli, Matteo, Winterhalter, Mathias
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742748/
https://ncbi.nlm.nih.gov/pubmed/26645688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.690156
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