Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta Cells

Cytosolic calcium influx activates signaling pathways known to support pancreatic beta cell function and survival by modulating gene expression. Impaired calcium signaling leads to decreased beta cell mass and diabetes. To appreciate the causes of these cytotoxic perturbations, a more detailed under...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Speckmann, Thilo, Sabatini, Paul V., Nian, Cuilan, Smith, Riley G., Lynn, Francis C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742737/
https://ncbi.nlm.nih.gov/pubmed/26663079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.704098
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