RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity

RUNX1/AML1 is among the most commonly mutated genes in human leukemia. Haploinsufficiency of RUNX1 causes familial platelet disorder with predisposition to myeloid malignancies (FPD/MM). However, the molecular mechanism of FPD/MM remains unknown. Here we show that murine Runx1(+/−) hematopoietic cel...

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Vydáno v:Blood Cancer J
Hlavní autoři: Chin, D W L, Sakurai, M, Nah, G S S, Du, L, Jacob, B, Yokomizo, T, Matsumura, T, Suda, T, Huang, G, Fu, X-Y, Ito, Y, Nakajima, H, Osato, M
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742622/
https://ncbi.nlm.nih.gov/pubmed/26745853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2015.105
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