Measuring the biological effect of presurgical metformin treatment in endometrial cancer

BACKGROUND: Preclinical studies in endometrial cancer (EC) show that metformin reduces cellular proliferation by PI3K-AKT-mTOR inhibition. We tested the hypothesis that short-term presurgical metformin reduces cellular proliferation in atypical endometrial hyperplasia (AEH) and endometrioid EC, and...

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Vydáno v:Br J Cancer
Hlavní autoři: Sivalingam, V N, Kitson, S, McVey, R, Roberts, C, Pemberton, P, Gilmour, K, Ali, S, Renehan, A G, Kitchener, H C, Crosbie, E J
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742583/
https://ncbi.nlm.nih.gov/pubmed/26794276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.453
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