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Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase‐activated receptor‐2

BACKGROUND AND PURPOSE: Neutrophil elastase plays a crucial role in arthritis. Here, its potential in triggering joint inflammation and pain was assessed, and whether these effects were mediated by proteinase‐activated receptor‐2 (PAR2). EXPERIMENTAL APPROACH: Neutrophil elastase (5 μg) was injected...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Muley, Milind M, Reid, Allison R, Botz, Bálint, Bölcskei, Kata, Helyes, Zsuzsanna, McDougall, Jason J
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742294/
https://ncbi.nlm.nih.gov/pubmed/26140667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13237
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