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Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase‐activated receptor‐2
BACKGROUND AND PURPOSE: Neutrophil elastase plays a crucial role in arthritis. Here, its potential in triggering joint inflammation and pain was assessed, and whether these effects were mediated by proteinase‐activated receptor‐2 (PAR2). EXPERIMENTAL APPROACH: Neutrophil elastase (5 μg) was injected...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4742294/ https://ncbi.nlm.nih.gov/pubmed/26140667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13237 |
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