Compound 21, a selective agonist of angiotensin AT(2) receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo

BACKGROUND AND PURPOSE: Angiotensin AT (2) receptors are upregulated in disease states such as atherosclerosis and blockade of the AT(2) receptors exacerbates plaque formation. Direct stimulation of these receptors is anti‐atherogenic but the mechanisms and pathways involved remain unknown. We exami...

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Publicado en:Br J Pharmacol
Autores principales: Sampson, Amanda K, Irvine, Jennifer C, Shihata, Waled A, Dragoljevic, Dragana, Lumsden, Natalie, Huet, Olivier, Barnes, Tyrone, Unger, Thomas, Steckelings, Ulrike M, Jennings, Garry L, Widdop, Robert E, Chin‐Dusting, Jaye P F
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2015
Materias:
Themed Section: Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742292/
https://ncbi.nlm.nih.gov/pubmed/25560767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13063
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