Compound 21, a selective agonist of angiotensin AT(2) receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo

BACKGROUND AND PURPOSE: Angiotensin AT (2) receptors are upregulated in disease states such as atherosclerosis and blockade of the AT(2) receptors exacerbates plaque formation. Direct stimulation of these receptors is anti‐atherogenic but the mechanisms and pathways involved remain unknown. We exami...

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Pubblicato in:Br J Pharmacol
Autori principali: Sampson, Amanda K, Irvine, Jennifer C, Shihata, Waled A, Dragoljevic, Dragana, Lumsden, Natalie, Huet, Olivier, Barnes, Tyrone, Unger, Thomas, Steckelings, Ulrike M, Jennings, Garry L, Widdop, Robert E, Chin‐Dusting, Jaye P F
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
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Themed Section: Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742292/
https://ncbi.nlm.nih.gov/pubmed/25560767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13063
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