A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy

BACKGROUND: Depending on the epidemiological setting, a variable proportion of leprosy patients will suffer from excessive pro-inflammatory responses, termed type-1 reactions (T1R). The LRRK2 gene encodes a multi-functional protein that has been shown to modulate pro-inflammatory responses. Variants...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Fava, Vinicius M., Manry, Jérémy, Cobat, Aurélie, Orlova, Marianna, Van Thuc, Nguyen, Ba, Nguyen Ngoc, Thai, Vu Hong, Abel, Laurent, Alcaïs, Alexandre, Schurr, Erwin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742274/
https://ncbi.nlm.nih.gov/pubmed/26844546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004412
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