CD44-mediated activation of α5β1-integrin, cortactin and paxillin signaling underpins adhesion of basal-like breast cancer cells to endothelium and Fibronectin-enriched matrices

CD44 expression is elevated in basal-like breast cancer (BLBC) tissue, and correlates with increased efficiency of distant metastasis in patients and experimental models. We sought to characterize mechanisms underpinning CD44-promoted adhesion of BLBC cells to vascular endothelial monolayers and ext...

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Veröffentlicht in:Oncotarget
Hauptverfasser: McFarlane, Suzanne, McFarlane, Cheryl, Montgomery, Nicola, Hill, Ashleigh, Waugh, David J.J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742209/
https://ncbi.nlm.nih.gov/pubmed/26447611
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