Regulation of SOX10 stability via ubiquitination-mediated degradation by Fbxw7α modulates melanoma cell migration

Dysregulation of SOX10 was reported to be correlated with the progression of multiple cancer types, including melanocytic tumors and tumors of the nervous system. However, the mechanisms by which SOX10 is dysregulated in these tumors are poorly understood. In this study, we report that SOX10 is a di...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Lv, Xiao-Bin, Wu, Wei, Tang, Xiaofeng, Wu, Yanqing, Zhu, Yinghua, Liu, Yujie, Cui, Xiuying, Chu, Junjun, Hu, Pengnan, Li, Jingjing, Guo, Qiannan, Cai, zeming, Wu, Juan, Hu, Kaishun, Ouyang, Nengyong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742183/
https://ncbi.nlm.nih.gov/pubmed/26461473
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