c-Maf regulates pluripotency genes, proliferation/self-renewal, and lineage commitment in ROS-mediated senescence of human mesenchymal stem cells

Mesenchymal stem cells (MSCs) are therapeutically relevant multilineage and immunomodulatory progenitors. Ex vivo expansion of these rare cells is necessary for clinical application and can result in detrimental senescent effects, with mechanisms still largely unknown. We found that vigorous ex vivo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Chen, Pei-Min, Lin, Chia-Hua, Li, Nan-Ting, Wu, Yao-Ming, Lin, Ming-Tsan, Hung, Shih-Chieh, Yen, Men-Luh
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper: Gerotarget (Focus on Aging)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742114/
https://ncbi.nlm.nih.gov/pubmed/26496036
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