Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells

Bortezomib inhibits the ubiquitin/proteasome pathway to achieve its anti-cancer effect and its well characterized activity is the NF-κB inhibition through which the anti-apoptotic bcl-2 expression is down-regulated and apoptosis is subsequently induced. However, the downstream molecular targets of b...

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Vydáno v:Oncotarget
Hlavní autoři: Ci, Xinyu, Li, Bingnan, Ma, Xueping, Kong, Feng, Zheng, Chengyun, Björkholm, Magnus, Jia, Jihui, Xu, Dawei
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741985/
https://ncbi.nlm.nih.gov/pubmed/26472030
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