Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response

The MUS81 protein belongs to a conserved family of DNA structure-specific nucleases that play important roles in DNA replication and repair. Inactivation of the Mus81 gene in mice has no major deleterious consequences for embryonic development, although cancer susceptibility has been reported. We ha...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Xing, Meichun, Wang, Xiaohui, Palmai-Pallag, Timea, Shen, Huahao, Helleday, Thomas, Hickson, Ian D., Ying, Songmin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741954/
https://ncbi.nlm.nih.gov/pubmed/26415217
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