OX40 expression enhances the prognostic significance of CD8 positive lymphocyte infiltration in colorectal cancer

BACKGROUND: OX40 is a TNF receptor family member expressed by activated T cells. Its triggering by OX40 ligand promotes lymphocyte survival and memory generation. Anti-OX40 agonistic monoclonal antibodies (mAb) are currently being tested in cancer immunotherapy. We explored the prognostic significan...

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Publicat a:Oncotarget
Autors principals: Weixler, Benjamin, Cremonesi, Eleonora, Sorge, Roberto, Muraro, Manuele Giuseppe, Delko, Tarik, Nebiker, Christian A., Däster, Silvio, Governa, Valeria, Amicarella, Francesca, Soysal, Savas D., Kettelhack, Christoph, von Holzen, Urs W., Eppenberger-Castori, Serenella, Spagnoli, Giulio C., Oertli, Daniel, Iezzi, Giandomenica, Terracciano, Luigi, Tornillo, Luigi, Sconocchia, Giuseppe, Droeser, Raoul A.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741950/
https://ncbi.nlm.nih.gov/pubmed/26439988
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