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Prolonged ovarian hormone deprivation alters the effects of 17β-estradiol on microRNA expression in the aged female rat hypothalamus

Administration of 17β-estradiol (E(2)) has beneficial effects on cognitive function in peri- but not post-menopausal women, yet the molecular mechanisms underlying age-related changes in E(2) action remain unclear. We propose that there is a biological switch in E(2) action that occurs coincident wi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Rao, Yathindar S., Shults, Cody L., Pinceti, Elena, Pak, Toni R.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741909/
https://ncbi.nlm.nih.gov/pubmed/26460619
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