CGK733-induced LC3 II formation is positively associated with the expression of cyclin-dependent kinase inhibitor p21(Waf1/Cip1) through modulation of the AMPK and PERK/CHOP signaling pathways

Microtubule-associated protein 1A/1B-light chain 3 (LC3)-II is essential for autophagosome formation and is widely used to monitor autophagic activity. We show that CGK733 induces LC3 II and LC3-puncta accumulation, which are not involved in the activation of autophagy. The treatment of CGK733 did n...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Yufeng, Kuramitsu, Yasuhiro, Baron, Byron, Kitagawa, Takao, Tokuda, Kazuhiro, Akada, Junko, Nakamura, Kazuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741855/
https://ncbi.nlm.nih.gov/pubmed/26486079
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