Mutant AKT1-E17K is oncogenic in lung epithelial cells

The hotspot E17K mutation in the pleckstrin homology domain of AKT1 occurs in approximately 0.6–2% of human lung cancers. In this manuscript, we sought to determine whether this AKT1 variant is a bona-fide activating mutation and plays a role in the development of lung cancer. Here we report that in...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: De Marco, Carmela, Malanga, Donatella, Rinaldo, Nicola, De Vita, Fernanda, Scrima, Marianna, Lovisa, Sara, Fabris, Linda, Carriero, Maria Vincenza, Franco, Renato, Rizzuto, Antonia, Baldassarre, Gustavo, Viglietto, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741851/
https://ncbi.nlm.nih.gov/pubmed/26053093
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