AKT1(E17K) Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer

The hotspot AKT1(E17K) mutation in the pleckstrin homology domain of AKT1 occurs in approximately 0.6–2% of human lung cancers. Recently, we have demonstrated that AKT1(E17K) transforms immortalized human bronchial cells. Here by use of a transgenic Cre-inducible murine strain in the wild type Rosa2...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Malanga, Donatella, Belmonte, Stefania, Colelli, Fabiana, Scarfò, Marzia, De Marco, Carmela, Oliveira, Duarte Mendes, Mirante, Teresa, Camastra, Caterina, Gagliardi, Monica, Rizzuto, Antonia, Mignogna, Chiara, Paciello, Orlando, Papparella, Serenella, Fagman, Henrik, Viglietto, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747507/
https://ncbi.nlm.nih.gov/pubmed/26859676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147334
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