High frequency of additional gene mutations in acute myeloid leukemia with MLL partial tandem duplication: DNMT3A mutation is associated with poor prognosis

The mutational profiles of acute myeloid leukemia (AML) with partial tandem duplication of mixed-lineage leukemia gene (MLL-PTD) have not been comprehensively studied. We studied 19 gene mutations for 98 patients with MLL-PTD AML to determine the mutation frequency and clinical correlations. MLL-PTD...

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Udgivet i:Oncotarget
Main Authors: Kao, Hsiao-Wen, Liang, Der-Cherng, Kuo, Ming-Chung, Wu, Jin-Hou, Dunn, Po, Wang, Po-Nan, Lin, Tung-Liang, Shih, Yu-Shu, Liang, Sung-Tzu, Lin, Tung-Huei, Lai, Chen-Yu, Lin, Chun-Hui, Shih, Lee-Yung
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741760/
https://ncbi.nlm.nih.gov/pubmed/26375248
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