Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor

HER2, a well established oncogenic member of EGFR family, is among the most intensely investigated kinase drug targets. In contrast to hotspot mutations of EGFR, few mutations of HER2 locate in activation loop within kinase domain. We previously reported the molecular mechanism underlying hyper kina...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hu, Zexi, Hu, Yong, Liu, Xicheng, Xi, Rongwen, Zhang, Aiqun, Liu, Deruo, Xie, Qiang, Chen, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741629/
https://ncbi.nlm.nih.gov/pubmed/26375550
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