Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma

Loss of the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a prerequisite for tumor cell-specific expression of vascular endothelial growth factor receptor (VEGFR)-2 in glioblastoma defining a subgroup prone to develop evasive resistance towards antiangiogenic tre...

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Pubblicato in:Oncotarget
Autori principali: Kessler, Tobias, Sahm, Felix, Blaes, Jonas, Osswald, Matthias, Rübmann, Petra, Milford, David, Urban, Severino, Jestaedt, Leonie, Heiland, Sabine, Bendszus, Martin, Hertenstein, Anne, Pfenning, Philipp-Niclas, de Almodóvar, Carmen Ruiz, Wick, Antje, Winkler, Frank, von Deimling, Andreas, Platten, Michael, Wick, Wolfgang, Weiler, Markus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741588/
https://ncbi.nlm.nih.gov/pubmed/25682871
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