A novel retroviral mutagenesis screen identifies prognostic genes in RUNX1 mediated myeloid leukemogenesis

Using a novel retroviral shuttle vector approach we identified genes that collaborate with a patient derived RUNX1 (AML1) mutant. RUNX1 mutations occurs in 40% of myelodysplastic syndromes (MDS). MDS are a group of hematopoietic stem cell disorders that are characterized by dysplasia that often prog...

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Publicado en:Oncotarget
Autores principales: Rae, Dustin T., Hocum, Jonah D., Bii, Victor, Deeg, H. Joachim, Trobridge, Grant D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper: Chromosome
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741560/
https://ncbi.nlm.nih.gov/pubmed/26384344
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