Inhibition of endoplasmic reticulum chaperone protein glucose-regulated protein 78 potentiates anti-angiogenic therapy in renal cell carcinoma through inactivation of the PERK/eIF2α pathway

Tumor microenvironments are characterized by decreased oxygen and nutrition due to the rapid and progressive nature of tumors and also stresses induced by several anti-tumor therapies. These intense cell stressors trigger a protective cell survival mechanism heralded by the unfolded protein response...

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Vydáno v:Oncotarget
Hlavní autoři: Han, Kyung Seok, Li, Na, Raven, Pater A., Fazli, Ladan, Frees, Sebastian, Ettinger, Susan, Park, Ki Chung, Hong, Sung Joon, Gleave, Martin E., So, Alan I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741492/
https://ncbi.nlm.nih.gov/pubmed/26472187
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