Systemic delivery of HER2-retargeted oncolytic-HSV by mesenchymal stromal cells protects from lung and brain metastases

Fully retargeted oncolytic herpes simplex viruses (o-HSVs) gain cancer-specificity from redirection of tropism to cancer-specific receptors, and are non-attenuated. To overcome the hurdles of systemic delivery, and enable oncolytic viruses (o-viruses) to reach metastatic sites, carrier cells are bei...

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發表在:Oncotarget
Main Authors: Leoni, Valerio, Gatta, Valentina, Palladini, Arianna, Nicoletti, Giordano, Ranieri, Dario, Dall'Ora, Massimiliano, Grosso, Valentina, Rossi, Martina, Alviano, Francesco, Bonsi, Laura, Nanni, Patrizia, Lollini, Pier-Luigi, Campadelli-Fiume, Gabriella
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2015
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741489/
https://ncbi.nlm.nih.gov/pubmed/26430966
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