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Convergence of cMyc and β‐catenin on Tcf7l1 enables endoderm specification

The molecular machinery that directs formation of definitive endoderm from pluripotent stem cells is not well understood. Wnt/β‐catenin and Nodal signalling have been implicated, but the requirements for lineage specification remain incompletely defined. Here, we demonstrate a potent effect of inhib...

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Detalles Bibliográficos
Publicado en:EMBO J
Main Authors: Morrison, Gillian, Scognamiglio, Roberta, Trumpp, Andreas, Smith, Austin
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741304/
https://ncbi.nlm.nih.gov/pubmed/26675138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592116
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