TET‐catalyzed oxidation of intragenic 5‐methylcytosine regulates CTCF‐dependent alternative splicing

Intragenic 5‐methylcytosine and CTCF mediate opposing effects on pre‐mRNA splicing: CTCF promotes inclusion of weak upstream exons through RNA polymerase II pausing, whereas 5‐methylcytosine evicts CTCF, leading to exon exclusion. However, the mechanisms governing dynamic DNA methylation at CTCF‐bin...

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Udgivet i:EMBO J
Main Authors: Marina, Ryan J, Sturgill, David, Bailly, Marc A, Thenoz, Morgan, Varma, Garima, Prigge, Maria F, Nanan, Kyster K, Shukla, Sanjeev, Haque, Nazmul, Oberdoerffer, Shalini
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741300/
https://ncbi.nlm.nih.gov/pubmed/26711177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593235
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