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Delivery of a Protease-Activated Cytolytic Peptide Prodrug by Perfluorocarbon Nanoparticles

Melittin is a cytolytic peptide derived from bee venom which inserts into lipid membranes and oligomerizes to form membrane pores. While this peptide is an attractive candidate for treatment of cancers and infectious processes, its nonspecific cytotoxicity and hemolytic activity have limited its the...

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Detalles Bibliográficos
Publicado en:Bioconjug Chem
Main Authors: Jallouk, Andrew P., Palekar, Rohun U., Marsh, Jon N., Pan, Hua, Pham, Christine T.N., Schlesinger, Paul H., Wickline, Samuel A.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740973/
https://ncbi.nlm.nih.gov/pubmed/26083278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.5b00246
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