Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum

DNA methylation (DNAm) levels lend themselves for defining an epigenetic biomarker of aging known as the ‘epigenetic clock'. Our genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identifies five significant (P<5.0 × 10(−8)) SNPs in two loci: 2p22.1 (inside gene D...

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Vydáno v:Nat Commun
Hlavní autoři: Lu, Ake T., Hannon, Eilis, Levine, Morgan E., Hao, Ke, Crimmins, Eileen M., Lunnon, Katie, Kozlenkov, Alexey, Mill, Jonathan, Dracheva, Stella, Horvath, Steve
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740877/
https://ncbi.nlm.nih.gov/pubmed/26830004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10561
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