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Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum

DNA methylation (DNAm) levels lend themselves for defining an epigenetic biomarker of aging known as the ‘epigenetic clock'. Our genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identifies five significant (P<5.0 × 10(−8)) SNPs in two loci: 2p22.1 (inside gene D...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lu, Ake T., Hannon, Eilis, Levine, Morgan E., Hao, Ke, Crimmins, Eileen M., Lunnon, Katie, Kozlenkov, Alexey, Mill, Jonathan, Dracheva, Stella, Horvath, Steve
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740877/
https://ncbi.nlm.nih.gov/pubmed/26830004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10561
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