Computational Analysis of AMPK-Mediated Neuroprotection Suggests Acute Excitotoxic Bioenergetics and Glucose Dynamics Are Regulated by a Minimal Set of Critical Reactions

Loss of ionic homeostasis during excitotoxic stress depletes ATP levels and activates the AMP-activated protein kinase (AMPK), re-establishing energy production by increased expression of glucose transporters on the plasma membrane. Here, we develop a computational model to test whether this AMPK-me...

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Pubblicato in:PLoS One
Autori principali: Connolly, Niamh M. C., D’Orsi, Beatrice, Monsefi, Naser, Huber, Heinrich J., Prehn, Jochen H. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740490/
https://ncbi.nlm.nih.gov/pubmed/26840769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148326
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