Recombinant Factor IX Fc Fusion Protein Maintains Full Procoagulant Properties and Exhibits Prolonged Efficacy in Hemophilia B Mice

INTRODUCTION: Hemophilia B is an inherited X chromosome–linked disorder characterized by impaired blood clotting owing to the absence of functional coagulation factor IX. Due to the relatively short half-life of factor IX, patients with hemophilia B require frequent factor IX infusions to maintain p...

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Publicado en:PLoS One
Main Authors: Toby, Garabet G., Liu, Tongyao, Buyue, Yang, Zhang, Xin, Bitonti, Alan J., Pierce, Glenn F., Sommer, Jurg M., Jiang, Haiyan, Peters, Robert T.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740463/
https://ncbi.nlm.nih.gov/pubmed/26840952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148255
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