The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes

The sigma-2 receptor (S2R) is a potential therapeutic target for cancer and neuronal diseases. However, the identity of the S2R has remained a matter of debate. Historically, the S2R has been defined as (1) a binding site with high affinity to 1,3-di-o-tolylguanidine (DTG) and haloperidol but not to...

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Udgivet i:EBioMedicine
Main Authors: Chu, Uyen B., Mavlyutov, Timur A., Chu, Ming-Liang, Yang, Huan, Schulman, Amanda, Mesangeau, Christophe, McCurdy, Christopher R., Guo, Lian-Wang, Ruoho, Arnold E.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740303/
https://ncbi.nlm.nih.gov/pubmed/26870805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.10.017
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