A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway

Identification of novel drug targets and affordable therapeutic agents remains a high priority in the fight against chronic hepatitis C virus (HCV) infection. Here, we report that the cellular proteins prohibitin 1 (PHB1) and 2 (PHB2) are pan-genotypic HCV entry factors functioning at a post-binding...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Liu, Shufeng, Wang, Wenyu, Brown, Lauren E., Qiu, Chao, Lajkiewicz, Neil, Zhao, Ting, Zhou, Jianhua, Porco, John A., Wang, Tony T.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740292/
https://ncbi.nlm.nih.gov/pubmed/26870784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.09.018
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