Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells

Non-CG methylation is an unexplored epigenetic hallmark of pluripotent stem cells. Here we report that a reduction in non-CG methylation is associated with impaired differentiation capacity into endodermal lineages. Genome-wide analysis of 2,670 non-CG sites in a discovery cohort of 25 phenotyped hu...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Butcher, Lee M., Ito, Mitsuteru, Brimpari, Minodora, Morris, Tiffany J., Soares, Filipa A. C., Ährlund-Richter, Lars, Carey, Nessa, Vallier, Ludovic, Ferguson-Smith, Anne C., Beck, Stephan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740175/
https://ncbi.nlm.nih.gov/pubmed/26822956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10458
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