Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

The main characteristic of senescence is its stability which relies on the persistence of DNA damage. We show that unlike fibroblasts, senescent epithelial cells do not activate an ATM-or ATR-dependent DNA damage response (DDR), but accumulate oxidative-stress-induced DNA single-strand breaks (SSBs)...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Nassour, Joe, Martien, Sébastien, Martin, Nathalie, Deruy, Emeric, Tomellini, Elisa, Malaquin, Nicolas, Bouali, Fatima, Sabatier, Laure, Wernert, Nicolas, Pinte, Sébastien, Gilson, Eric, Pourtier, Albin, Pluquet, Olivier, Abbadie, Corinne
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740115/
https://ncbi.nlm.nih.gov/pubmed/26822533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10399
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