Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

The main characteristic of senescence is its stability which relies on the persistence of DNA damage. We show that unlike fibroblasts, senescent epithelial cells do not activate an ATM-or ATR-dependent DNA damage response (DDR), but accumulate oxidative-stress-induced DNA single-strand breaks (SSBs)...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Nassour, Joe, Martien, Sébastien, Martin, Nathalie, Deruy, Emeric, Tomellini, Elisa, Malaquin, Nicolas, Bouali, Fatima, Sabatier, Laure, Wernert, Nicolas, Pinte, Sébastien, Gilson, Eric, Pourtier, Albin, Pluquet, Olivier, Abbadie, Corinne
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740115/
https://ncbi.nlm.nih.gov/pubmed/26822533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10399
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