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ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas
Tumor-initiating stem cells (SCs) exhibit distinct patterns of transcription factors and gene expression compared to healthy counterparts. Here, we show that dramatic shifts in large open-chromatin domain (super-enhancer) landscapes underlie these differences and reflect tumor microenvironment. By i...
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| Pubblicato in: | eLife |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4739765/ https://ncbi.nlm.nih.gov/pubmed/26590320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10870 |
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