BRCA1 regulation of Epidermal Growth Factor Receptor (EGFR) Expression in Human Breast Cancer Cells involves MicroRNA-146a and is Critical for its Tumor Suppressor Function

BRCA1-associated breast cancers are mostly basal-like high-grade ductal carcinomas that frequently overexpress epidermal growth factor receptor (EGFR). Aberrant EGFR expression is correlated with disease progression, resistance to radiation and chemotherapy, and poor clinical prognosis. While BRCA1...

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Publicado no:Oncogene
Main Authors: Kumaraswamy, Easwari, Wendt, Karen L., Augustine, Laura A., Stecklein, Shane R., Sibala, Emily C., Li, Dan, Gunewardena, Sumedha, Jensen, Roy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739738/
https://ncbi.nlm.nih.gov/pubmed/25417703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.363
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