Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression

The unintended consequences of gene targeting in mouse models have not been thoroughly studied and a more systematic analysis is needed to understand the frequency and characteristics of off-target effects. Using RNA-seq, we evaluated targeted and neighboring gene expression in tissues from 44 homoz...

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Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: West, David B., Engelhard, Eric K., Adkisson, Michael, Nava, A. J., Kirov, Julia V., Cipollone, Andreanna, Willis, Brandon, Rapp, Jared, de Jong, Pieter J., Lloyd, Kent C.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739719/
https://ncbi.nlm.nih.gov/pubmed/26839965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005691
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