Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome

Elevated fumarate concentrations as a result of Krebs cycle inhibition lead to increases in protein succination, an irreversible post-translational modification that occurs when fumarate reacts with cysteine residues to generate S-(2-succino)cysteine (2SC). Metabolic events that reduce NADH re-oxida...

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Bibliographic Details
Published in:Mol Cell Proteomics
Main Authors: Piroli, Gerardo G., Manuel, Allison M., Clapper, Anna C., Walla, Michael D., Baatz, John E., Palmiter, Richard D., Quintana, Albert, Frizzell, Norma
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2016
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Special Issue Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739666/
https://ncbi.nlm.nih.gov/pubmed/26450614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.051516
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