A Temperature Sensitive Variant of p53 Drives p53-Dependent MicroRNA Expression without Evidence of Widespread Post-Transcriptional Gene Silencing

The p53 tumour suppressor is a transcription factor that can regulate the expression of numerous genes including many encoding proteins and microRNAs (miRNAs). The predominant outcomes of a typical p53 response are the initiation of apoptotic cascades and the activation of cell cycle checkpoints. HT...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cabrita, Miguel A., Vanzyl, Erin J., Hamill, Jeff D., Pan, Elysia, Marcellus, Kristen A., Tolls, Victoria J., Alonzi, Rhea C., Pastic, Alyssa, Rambo, Teeghan M. E., Sayed, Hadil, McKay, Bruce C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739602/
https://ncbi.nlm.nih.gov/pubmed/26840126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148529
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