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Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1.

Gene targeting was used to produce mice deficient in intercellular adhesion molecule 1 (ICAM-1) or CD54, an immunoglobulin-like cell adhesion molecule that binds beta 2 integrins. Homozygous deficient animals develop normally, are fertile, and have a moderate granulocytosis. The nature of the mutati...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Sligh, J E, Ballantyne, C M, Rich, S S, Hawkins, H K, Smith, C W, Bradley, A, Beaudet, A L
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47390/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8104338/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.18.8529
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