BDNF contributes to IBS-like colonic hypersensitivity via activating the enteroglia-nerve unit

The over-expressed colonic brain-derived neurotrophic factor (BDNF) has been reported to be associated with abdominal pain in patients with irritable bowel syndrome (IBS). However, the neuropathological mechanism is unclear. We here investigated the involvement of enteroglial cells (EGCs) and enteri...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Wang, Peng, Du, Chao, Chen, Fei-Xue, Li, Chang-Qing, Yu, Yan-Bo, Han, Ting, Akhtar, Suhail, Zuo, Xiu-Li, Tan, Xiao-Di, Li, Yan-Qing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738267/
https://ncbi.nlm.nih.gov/pubmed/26837784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20320
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