Deficiency or inhibition of lysophosphatidic acid receptor 1 protects against hyperoxia-induced lung injury in neonatal rats

AIM: Blocking of lysophosphatidic acid (LPA) receptor (LPAR) 1 may be a novel therapeutic option for bronchopulmonary dysplasia (BPD) by preventing the LPAR1-mediated adverse effects of its ligand (LPA), consisting of lung inflammation, pulmonary arterial hypertension (PAH) and fibrosis. METHODS: In...

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Bibliographic Details
Published in:Acta Physiol (Oxf)
Main Authors: Chen, Xueyu, Walther, Frans J, van Boxtel, Ruben, Laghmani, El Houari, Sengers, Rozemarijn M A, Folkerts, Gert, DeRuiter, Marco C., Cuppen, Edwin, Wagenaar, Gerry T M
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738067/
https://ncbi.nlm.nih.gov/pubmed/26495902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apha.12622
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