Unique Flap Conformation in an HIV-1 Protease with High-Level Darunavir Resistance

Darunavir (DRV) is one of the most powerful protease inhibitors (PIs) for treating human immunodeficiency virus type-1 (HIV-1) infection and presents a high genetic barrier to the generation of resistant viruses. However, DRV-resistant HIV-1 infrequently emerges from viruses exhibiting resistance to...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Nakashima, Masaaki, Ode, Hirotaka, Suzuki, Koji, Fujino, Masayuki, Maejima, Masami, Kimura, Yuki, Masaoka, Takashi, Hattori, Junko, Matsuda, Masakazu, Hachiya, Atsuko, Yokomaku, Yoshiyuki, Suzuki, Atsuo, Watanabe, Nobuhisa, Sugiura, Wataru, Iwatani, Yasumasa
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737996/
https://ncbi.nlm.nih.gov/pubmed/26870021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2016.00061
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