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BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis

BACKGROUND: Mutations in the gene encoding the bone morphogenetic protein receptor type II (BMPR2) are the commonest genetic cause of pulmonary arterial hypertension (PAH). However, the effect of BMPR2 mutations on clinical phenotype and outcomes remains uncertain. METHODS: We analysed individual pa...

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Detalhes bibliográficos
Publicado no:Lancet Respir Med
Main Authors: Evans, Jonathan D W, Girerd, Barbara, Montani, David, Wang, Xiao-Jian, Galiè, Nazzareno, Austin, Eric D, Elliott, Greg, Asano, Koichiro, Grünig, Ekkehard, Yan, Yi, Jing, Zhi-Cheng, Manes, Alessandra, Palazzini, Massimiliano, Wheeler, Lisa A, Nakayama, Ikue, Satoh, Toru, Eichstaedt, Christina, Hinderhofer, Katrin, Wolf, Matthias, Rosenzweig, Erika B, Chung, Wendy K, Soubrier, Florent, Simonneau, Gérald, Sitbon, Olivier, Gräf, Stefan, Kaptoge, Stephen, Di Angelantonio, Emanuele, Humbert, Marc, Morrell, Nicholas W
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737700/
https://ncbi.nlm.nih.gov/pubmed/26795434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S2213-2600(15)00544-5
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